Life would have been much easier if human eye could visualize, with high enough resolution and fast enough speed, biomolecules performing their tasks – for example a live view of an RNA base being extruded out of the helical stack upon binding of a drug molecule would directly tell us the binding mode and other biophysical details needed to design the drug effectively and efficiently. Until we attain those powers, we have to rely on spectroscopy to indirectly visualize such motions in biomolecules.
We are developing methods using NMR experiments combined with other biophysical techniques and computational approaches to study dynamics of RNA and interacting proteins at atomic resolution. These dynamic ensembles help us visualize the detailed biomolecular behavior upon getting a cellular signal.
We are housed at Indian Institute of Science Education and Research (IISER), Pune, Maharashtra, India.
PhD positions: Starting Aug 2013 – I am welcoming applications from students trained in any branch of science and engineering. Students must clear the PhD entrance of IISER and then write to me with your CV and a one page proposal about what you want to do in the lab.
Project positions: Starting Jan 2014 – I am welcoming applications from students who want to gain experience in different aspects of biophysics involving proteins and nucleic acids and NMR spectroscopy. Students must come with a fellowship, your CV and a one page proposal about what you are interested in.